How to exclude files in temp folders

I have a user that is trying to download and install a legitimate application. The file is able to be downloaded. On executing, the app seems to create an executable in a randomly-named temp folder. Because the temp folder is randomly created, I am not able to provide a full path to the executable for exclusion purposes.

How can I deal with files like this?

Error message snippets:

At least one security risk found:

Risk name: Trojan.Gen.8
File path: C:\Users\username\AppData\Local\Temp\is-KSG9M.tmp\PTDownloader.exe

At least one security risk found:

Risk name: Trojan.Gen.8
File path: C:\Users\username\AppData\Local\Temp\is-OV65Q.tmp\PTDownloader.exe

At least one security risk found:

Risk name: Trojan.Gen.8
File path: C:\Users\usernamel\AppData\Local\Temp\is-16R5O.tmp\PTDownloader.exe

At least one security risk found:

Risk name: Trojan.Gen.8
File path: C:\Users\username\AppData\Local\Temp\is-5QRS1.tmp\PTDownloader.exe

These are all multiple attempts to download the same file. How can I allow the users to download this file?