Replication between two sites - SEPM

Dear Support,

We would like to ask some questions related to SEPM upgrade with replication.

Background Information

• We have deployed two SPEM in our environment.One is in Hong Kong and other one is in Singapore. Currently we have enabled replication between two sites via WAN link.
• SPEM are installed on Windows Server 2008 R2 and running embedded database. 
• Current version of SEPM is 12.1.5337.5000 (RU5) , plan to upgr​ade to 12.1.6 (RU6 MP6).

Question
Q1.Have any issue if we disable replication between two sites for a long time ? 
Q2.How long can replication disable ? e.g. 1 week / 1 month / no limitation
Q3.What is impact if we disable replication for long time ?
Q4.Could we reenable the replication between two sites after long period of time?

Please kindly advise.

Thanks
Kidd