SEP Client Definitions gets corrupted frerquently

Good Morning,

There is an issue on some of the server machines, where the virus definitions get corrupted frequently, due to which the clients on the server machine stop downloading defiitions from Live Update Administrator Server, GUP and SEPM.

However if we repair the client on the Server machine it starts taking update for some days and then again the same issue persist. Servers include 2000/2003/2008/2012.

Please can anyone provide a permanent solution for this issue, as repairing clients everytime is not possible.

Thanks and Regards.