Server cannot process request

I recently upgraded to SEPM 12.1.6 on a Windows 2008 R2 Server.

I can not connect my client endpoints to the server. I have replaced the sylink file and I have traffic going to the server. I am getting the error "server can not process request."

Also, I ran Symhelp on the SEPM and it shows one error, "One or more default ports for Symantec Endpoint Protection Manager are not free.""The process dbsrv16 (Process ID 1512) is listening on the Symantec Endpoint Protection Manager default port 2638."

I've check the ports and that process has an established link on that port. I am curious if this error has anything to do with my clients not being able to connect.

Thank you in advance for any help or advice.